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The Lock and Key of MedicineMonoclonal Antibodies and the Transformation of Healthcare$
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Lara V Marks

Print publication date: 2015

Print ISBN-13: 9780300167733

Published to Yale Scholarship Online: January 2016

DOI: 10.12987/yale/9780300167733.001.0001

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The First Medical Applications

The First Medical Applications

(p.69) Chapter Four The First Medical Applications
The Lock and Key of Medicine

Lara V. Marks

Yale University Press

This chapter describes the early clinical applications of monoclonal antibodies (Mabs). The technology offered so many different possibilities that it was difficult to know where to start. Many of Mabs' early applications appeared to have little overall pattern or logic, but their most effective uses were quickly established. In this process new relationships were forged between research scientists and industry, and Mabs' influence came to extend well beyond the confines of the small-scale laboratory. Researchers sought a wide range of applications for Mabs, including in the areas of immunology, parasitology, virology, bacteriology, oncology, endocrinology, hematology, pharmacology, and embryology. Mabs generated some of the greatest excitement in their potential to help purify natural substances and for blood and tissue typing.

Keywords:   Mabs, monoclonal antibodies, purification, natural substances, clinical applications, blood typing, tissue typing

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