Crossing Fields: Chemical Bonds to Biological Mutants
Crossing Fields: Chemical Bonds to Biological Mutants
This chapter discusses Meselson's view that, in order to approach the design of the replication experiment of which he dreamed, he must first understand in detail the structure and chemistry of the deoxyribonucleic acid molecule. This was not because the success of the experiment would necessarily depend on such knowledge but because it was part of the culture of Pauling's chemistry department that one would not be taken seriously until one had mastered the structure of any molecule in which one was interested. Feeling totally ignorant of the structures and properties of the purines and pyrimidines that comprised the inner structure of the double helix, Meselson set out to acquire a basic literacy in the subject.
Keywords: replication experiment, chemistry, deoxyribonucleic acid molecule, Pauling's chemistry department, purines, pyrimidines, inner structure, double helix
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