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The Lock and Key of MedicineMonoclonal Antibodies and the Transformation of Healthcare$
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Lara V Marks

Print publication date: 2015

Print ISBN-13: 9780300167733

Published to Yale Scholarship Online: January 2016

DOI: 10.12987/yale/9780300167733.001.0001

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Breakthroughs at the Bench

Breakthroughs at the Bench

(p.47) Chapter Three Breakthroughs at the Bench
The Lock and Key of Medicine

Lara V. Marks

Yale University Press

This chapter discusses how monoclonal antibodies (Mabs) opened new frontiers in research well beyond immunology and transformed the way scientists analyzed biological phenomena in the early 1980s. Some of the earliest discoveries made possible by Mabs were related to the brain and the central nervous system. Yet these advances were just the tip of the iceberg as scientists began to realize the power of Mabs for exploring the vast number of human differentiation antigens, proteins located on the cell surface of immune cells. Before the arrival of Mabs, scientists had little knowledge of the surface of immune cells. Their subsequent investigations into human differentiation antigens would not only advance understandings about the network of interactions that govern the immune response, but also help identify new targets for diagnostic and therapeutic interventions that would have profound implications for human health.

Keywords:   Mabs, monoclonal antibodies, scientific research, brain, central nervous system, human differentiation antigens, immune cells

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