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BannedA History of Pesticides and the Science of Toxicology$
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Frederick Rowe Davis

Print publication date: 2014

Print ISBN-13: 9780300205176

Published to Yale Scholarship Online: May 2015

DOI: 10.12987/yale/9780300205176.001.0001

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The Toxicity of Organophosphate Chemicals

The Toxicity of Organophosphate Chemicals

(p.91) Chapter 4 The Toxicity of Organophosphate Chemicals

Frederick Rowe Davis

Yale University Press

This chapter examines organophosphate insecticides, focusing on DDT and other chlorinated hydrocarbons. These chemicals demanded novel toxicological techniques and strategies. During World War II, the Toxicity Laboratory at the University of Chicago responded to this requirement. Kenneth DuBois and his colleagues recognized the major toxicological effects of organophosphates: cholinesterase inhibition. DuBois and his research group developed toxicological profiles for many of the new insecticides, including OMPA and parathion. Meanwhile, David Grob at Johns Hopkins examined the toxicity of parathion to humans, drawing on occupational cases of exposure. Arnold Lehman at the FDA also evaluated the risks of the organophosphates, particularly in comparison to other insecticides like the chlorinated hydrocarbons.

Keywords:   Kenneth Dubois, Toxicity Lab, chlorinated hydrocarbons, cholinesterase inhibition, Arnold Lehman, parathion, David Grob

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