How can the United States chart a path forward in the war on drugs? This book uncovers the full history of this war that has lasted more than a century. The book provides an essential view of the economic, political, and human impacts of U.S. drug policies. It takes readers from Afghanistan to Colombia, to Peru and Mexico, to Miami International Airport and the border crossing between El Paso and Juarez to trace the complex social networks that make up the drug trade and drug consumption. Through historically driven stories, the book reveals how the war on drugs has evolved to address mass incarceration, the opioid epidemic, the legalization and medical use of marijuana, and America's shifting foreign policy.